Titlebook: Skeletal Development and Repair; Methods and Protocol Matthew J. Hilton Book 2014 Springer Science+Business Media, LLC 2014 cell assays.ske

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Generation of Closed Transverse Fractures in Small Animalsesses that may be assessed and the types of research questions that may be addressed with this model are briefly outlined. The detailed surgical protocol to generate closed simple transverse fractures is presented, and general considerations when setting up an experiment using this model are describ

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The Murine Femoral Bone Graft Model and a Semiautomated Histomorphometric Analysis Tooland complications of fracture healing. Over the last decade, the murine femoral allograft model has gained popularity due to its standardized surgery and potential for examining a vast array of radiographic, biomechanical, and histological outcome measures. Here, we describe these methods and a nove

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Surgical Induction of Posttraumatic Osteoarthritis in the Mouseathogenic basis of disease and developing novel disease-modifying OA therapies. Because of the well-documented central role that joint trauma plays in the initiation of knee OA, large animal and rodent models of knee injury that accurately recapitulate the OA disease process have become increasingly

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Cartilage Explant Culturestilaginous skeletal elements. In these organ cultures, the arrangement of chondrocytes in the cartilage elements and their interaction with the surrounding perichondrium and joint tissue are maintained. Chondrocyte proliferation and differentiation can thus be studied under nearly in vivo conditions

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