Titlebook: Short-Term Test Systems for Detecting Carcinogens; K. H. Norpoth,R. C. Garner Conference proceedings 1980 Springer-Verlag Berlin Heidelber

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门闩

https://doi.org/10.1007/978-3-642-67202-6DNA; Mutagenicity; cancer; cell; cell culture; etiology; liver; mutagen; screening

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978-3-642-67204-0Springer-Verlag Berlin Heidelberg 1980

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OpeningLadies and gentlemen, on behalf of the president of the Federal Institute of Occupational Safety and Accident Research, Prof. Hagenkötter, I welcome you in Dortmund to day on the occasion of the International Symposium on Short-Term Mutagenicity Test Systems for Detecting Carcinogens.

Platelet

Correlations Between Primary Effects of Xenobiotics on Liver Cells in Vitro and Their Mutagenicity aNumerous studies have established a high degree of correlation between the carcinogenicity of chemical compounds and their mutagenic potential. This fact not only supports the somatic mutation theory, but has also been successfully used to identify and eliminate carcinogenic compounds from the human environment (1).

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In Vitro Assays to Predict Carcinogenicity?otential and not of potency. They also cannot indicate whether man is susceptible or resistant to the test substance. Examples of the various factors involved in tumour initiation are presented using aflatoxins, aromatic amines and some direct-acting carcinogens as models.

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