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Titlebook: Short-Term Test Systems for Detecting Carcinogens; K. H. Norpoth,R. C. Garner Conference proceedings 1980 Springer-Verlag Berlin Heidelber

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The Microbial Host-Mediated Assay in Comparison with in Vitro Systems: Problems of Evaluation, Prediare not mutagenic themselves. On the other hand, by applying this test system, relationship may be established between the mutagenic effect of a test substance in the animal and the dosage which is required to produce it..The applicability of this test system is demonstrated by results which were ob
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Mutagenic and Carcinogenic Effects of Antimetabolitess, varying both chemically (here we could mention various azo, nitro, and nitroso compounds, metal complexes with organic ligands, acids and their numerous derivatives, etc.) and biologically active substances (such as pesticides, herbicides, industrial poisons, pharmaceutical and perfumery products
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Mutagen-Metabolizing Enzymes in Mammalian Cell Cultures: Possibilities and Limitations for Mutagenicl factor for their applicability as screening systems for mutagenicity is their capacity to metabolize premutagens to their reactive forms. Indeed, in cultured mammalian cells as well as in other in vitro test systems the metabolic activation of chemicals is the facet which most frequently gives ris
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Studies on the Detection of Carcinogens Using a Mammalian Cell Transformation Assay with Liver Homog having a different end-point such as changes in morphology, plating efficiency, serum requirement, nuclear size, enzyme activity, growth in semi-solid agar, cyto-skeletal structure and antigenicity. These changes appear to be acquired by primary cells at different times following exposure to a carc
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The Significance and Interpretation of in Vitro Carcinogenicity Assay Resultsr example, few people would disagree with attempts to remove a recognizable source of potential hazard, such as the presence of a potent animal carcinogen in drinking water, but many would question whether abrupt action should be taken on finding that hamburgers contain chemicals mutagenic to ..
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Some Aspects of Bacterial Mutagenicity Testingys (6–8), but their main role lies in the primary detection of environmental chemicals to be further evaluated for mutagenic and carcinogenic hazards, and several systems in bacteria such as . and . have been described (see 9 and 10).
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