| 书目名称 | Short-Term Test Systems for Detecting Carcinogens |
| 编辑 | K. H. Norpoth,R. C. Garner |
| 视频video | http://file.papertrans.cn/867/866750/866750.mp4 |
| 图书封面 |  |
| 描述 | The varying cancer incidence from country to country and region to region suggests that en vironmental factors play a considerable role in the aetiology of cancer. Whether these factors in the environment moderate the effect of car cinogenic chemicals or whether they might them selves be carcinogenic is not known at the present time. What is known is that there are various chemicals, both naturally occurring and man-made, which can induce cancer in man. In the Western world estimates vary as to how much cancer is occupational in origin; the figures range from 1% to 40%. It is our feeling that probably about 10% of cancer has a direct oc cupational origin. Nevertheless this number is considerable and it behoves us therefore to identify those chemicals which are carcinogenic and to reduce human exposure. Recent work on the mode of action of carcinogenic chemicals suggests that the majority exert their effect through an activation step to give elec trophilic metabolites. Such metabolites have as a common feature the ability to react with cel lular nucleophiles to give covalently bound products. Such reaction will occur after carcino gen treatment of animals with nucleic acids p |
| 出版日期 | Conference proceedings 1980 |
| 关键词 | DNA; Mutagenicity; cancer; cell; cell culture; etiology; liver; mutagen; screening |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-642-67202-6 |
| isbn_softcover | 978-3-642-67204-0 |
| isbn_ebook | 978-3-642-67202-6 |
| copyright | Springer-Verlag Berlin Heidelberg 1980 |
|Archiver|手机版|小黑屋|
派博传思国际
( 京公网安备110108008328)
GMT+8, 2025-8-20 03:35
发表于 2025-3-21 16:42:17
