Titlebook: Serotonin: Molecular Biology, Receptors and Functional Effects; John R. Fozard,Pramod R. Saxena Book 1991 Birkhäuser Verlag 1991 biology.d

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Serotonin Trophic Factors in Development, Plasticity and Agingf the most plastic neurotransmitter systems in the brain — that is after lesioning of terminals, the serotonin neuron has the capacity to regenerate them. In order for the phenomena of plasticity to take place, some of the trophic (or growth-promoting) molecules present during development, must be present even in the adult brain.

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Developmental and Synaptic Regulation of 5-HT2 and 5-HT1c Serotonin Receptorsuncharacterized. To clarify some of these we investigated the effects of (1) normal perinatal development and (2) acute and chronic receptor blockade on the levels of 5-HT. and 5-HT. receptor binding and mRNAs. During rat brain development, 5-HT. receptors increased 8-fold while 5-HT. receptor mRNA

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A Neurotrophic Factor — SNTF — for Serotonergic Neurons]. Specific denervation of 5-HT fibers from the hippocampus [by 5,7-dihydroxytryptamine injection in the afferent pathway] induces 5-HT homotypic collateral sprouting in a month. The 5-HT-denervated hippocampus was shown to be a rich environment for the growth of grafted fetal 5-HT neurons. Grafted