Titlebook: Serotonin: Molecular Biology, Receptors and Functional Effects; John R. Fozard,Pramod R. Saxena Book 1991 Birkhäuser Verlag 1991 biology.d

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Cloning and Expression of a Human 5-HT1D Receptor 5-HT. receptor. Since the deduced amino acid sequence of this gene exhibits only moderate homology to the 5-HT. receptor and low homology to 5-HT. receptor subfamily (5-HT. and 5-HT. receptors), the human 5-HT. receptor apparently represents the first member of a new subfamily of serotonin receptor

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Developmental and Synaptic Regulation of 5-HT2 and 5-HT1c Serotonin ReceptorsA small increase in 5-HT. receptor mRNA (20–25%) was seen after 10 and 21 days of continuous mianserin treatment while 5-HT. receptor mRNA levels were unchanged. These results indicate that mianserin decreases 5-HT. and 5-HT. receptors without altering steady-state mRNA levels.

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A Neurotrophic Factor — SNTF — for Serotonergic Neuronsn added to grafted 5-HT neurons increased the 5-HT content of fetal 5-HT neurons in the normal hippocampus. The grafted 5-HT neurons and trophic extracts were also tested in the cerebellum, a brain region with sparse 5-HT innervation. We found that grafted 5-HT neurons seldom survived in this brain

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Molecular Mechanisms of Action Induced by 5-HT3 Receptors in a Neuronal Cell Line and by 5-HT2 Recepce, and consequent entry of extracellular Ca.. In the neuronal cell line, serotonin induces a rise of the cyclic GMP level, which depends on the rise of cytosolic Ca. activity. This conclusion is derived from the following findings: The serotonin-stimulated rise of cyclic GMP level is inhibited by i

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Second Messengers in the Definition of 5-HT Receptorsstablished for 5-HT. receptor-mediated stimulation of phospholipase C will be especially useful in the definition of functional 5-HT. receptors, although 5-HT. and 5-HT. receptors have similar pharmacological profiles and second messenger systems. 5-HT. receptors form ligand gated channels and thus,

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5-HT1P Receptors in the Bowel: G Protein Coupling, Localization, and Functionelevate levels of cAMP in preparations of isolated myenteric ganglia. Renzapride also increased cAMP, but the response neither to 5-HT nor to renzapride was inhibited by the 5-HT. antagonist, N-acetyl-5-hydroxytryptophyl-5-hydroxytryptophan amide (5-HTP-DP) or the 5-HT./5-HT. antagonist, ICS 205–930

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