Titlebook: Sequential Experimentation in Clinical Trials; Design and Analysis Jay Bartroff,Tze Leung Lai,Mei-Chiung Shih Book 2013 Springer Science+Bu

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Jay Bartroff,Tze Leung Lai,Mei-Chiung Shihof reducing the concept of finite procedure to that of a machine with a finite number of parts, as has been done by the British mathematician Turing. As for the philosophical consequences of the results under consideration, I don’t think they have ever been adequately discussed or only taken notice

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Jay Bartroff,Tze Leung Lai,Mei-Chiung ShihInterdisciplinary approach that Statistics researchers and advanced students will use, in addition to Statisticians working in medical fields.Includes recent work that provides a new class of adaptive

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Introduction,al methods to design and analyze these sequential experiments in evidence-based medical research. In this connection it also gives an outline of the topics covered in the subsequent chapters and discusses the complementary roles of Bayesian and frequentist approaches to sequential design and analysis.

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Nonlinear Regression, Experimental Design, and Phase I Clinical Trials, at a level where some positive response occurs, and healthy volunteers are often used as study subjects. In Sect. 2.2 we describe some basic pharmacologic principles and models underlying dose determination.

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Sequential Methods for Vaccine Safety Evaluation and Surveillance in Public Health,ine clinical trials and post-marketing safety evaluation. Section 5.1 describes typical design considerations for vaccine safety evaluation and the application of the SPRT and its other sequential tests that have been applied to test vaccine safety.

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