Titlebook: Sequential Experimentation in Clinical Trials; Design and Analysis Jay Bartroff,Tze Leung Lai,Mei-Chiung Shih Book 2013 Springer Science+Bu

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0172-7397 s.Includes recent work that provides a new class of adaptive.Sequential Experimentation in Clinical Trials: Design and Analysis. is developed from decades of work in research groups, statistical pedagogy, and workshop participation. Different parts of the book can be used for short courses on clinic

Indigence

Sequential Testing Theory and Stochastic Optimization Over Time,ynamic programming that is also introduced in that section for general stochastic optimization over time. Dynamic programming is often difficult to implement directly for nonlinear models and approximate dynamic programming (ADP) methods have been developed to overcome the computational and analytical difficulties.

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Confidence Intervals and ,-Values,es an overview of several developments in the literature to address this issue. Most of them focus on the simple case of a normal mean μ with known variance, for which “exact methods” to construct confidence intervals for μ following a group sequential test of μ ≤ 0 (or of μ = 0) are available.

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Book 2013orkshop participation. Different parts of the book can be used for short courses on clinical trials, translational medical research, and sequential experimentation. The authors have successfully used the book to teach innovative clinical trial designs and statistical methods for Statistics Ph.D. stu

外面

Introduction,al methods to design and analyze these sequential experiments in evidence-based medical research. In this connection it also gives an outline of the topics covered in the subsequent chapters and discusses the complementary roles of Bayesian and frequentist approaches to sequential design and analysi

Truculent

Nonlinear Regression, Experimental Design, and Phase I Clinical Trials, at a level where some positive response occurs, and healthy volunteers are often used as study subjects. In Sect. 2.2 we describe some basic pharmacologic principles and models underlying dose determination.

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垫子

Sequential Methods for Vaccine Safety Evaluation and Surveillance in Public Health,ine clinical trials and post-marketing safety evaluation. Section 5.1 describes typical design considerations for vaccine safety evaluation and the application of the SPRT and its other sequential tests that have been applied to test vaccine safety.