Titlebook: Senolytics in Disease, Ageing and Longevity; Daniel Muñoz-Espin,Marco Demaria Book 2020 The Editor(s) (if applicable) and The Author(s), u

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Pilar Picallos-Rabina,Sabela Da Silva-Álvarez,Lucía Antelo-Iglesias,Francisco Triana-Martínez,Manuely associate with the logical empiricists, although, as we now know, it derives in reality from Wittgenstein, and the second is in relation to the theory of meaning for intuitionistic logic that has been developed, beginning of course with Brouwer, Heyting and Kolmogorov in the 1920s and early 1930s

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Ioannis S. Pateras,Sofia D. P. Theodorou,Niki V. Chouliari,Dimitris Veroutis,Panagiotis-Georgios Pasnd World War. Allied war crime tribunals based themselves on international law, and the judges were accused of the same crimes as other war criminals. The defendants were accused of participating in war crimes in their roles as leading officials in the Ministry of Justice and as prosecutors and judg

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Beatriz Lozano-Torres,Juan F. Blandez,Félix Sancenón,Ramón Martínez-Máñeznd World War. Allied war crime tribunals based themselves on international law, and the judges were accused of the same crimes as other war criminals. The defendants were accused of participating in war crimes in their roles as leading officials in the Ministry of Justice and as prosecutors and judg

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Antonio Leonardi,Francesco Pacifico,Elvira Crescenzind World War. Allied war crime tribunals based themselves on international law, and the judges were accused of the same crimes as other war criminals. The defendants were accused of participating in war crimes in their roles as leading officials in the Ministry of Justice and as prosecutors and judg

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Senolytics Target Senescent Cells and Improve Aging and Age-Related Diseasesg their resistance to apoptosis, by reactivating latent p53 or by increasing oxidative stress. Other compounds inhibit the senescence associated secretory phenotype or SASP. Senolytics and SASP modulators have been effective to improve natural aging and age-related diseases in mice models leading to ongoing clinical trials in humans.

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Senolytic Drug DevelopmentSelectively eliminating SnCs has been emerging as a new strategy for treating age-related diseases and extending healthspan. Small molecules that targeting different SnC anti-apoptotic pathways (SCAPs) to selectively kill SnCs are termed senolytics. Up to date, several classes of senolytic agents, i

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Discovery of Senolytics and the Pathway to Early Phase Clinical Trialsrete factors that cause dysfunction at local and systemic levels. The discovery of senolytics, drugs that specifically target senescent cells, has opened an innovative pathway for treating age-related diseases. Successes in pre-clinical models have led to first-in-human trials. If effective, senolyt

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Interconnection Between Cellular Senescence, Regeneration and Ageing in Salamanders induction of cellular senescence during limb regeneration. The dynamics of senescence in this context reflects that observed in acute senescence, suggesting that senescent cells may play positive roles in regeneration. Further, salamanders possess a highly robust and efficient mechanism for senesce