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Titlebook: Senolytics in Disease, Ageing and Longevity; Daniel Muñoz-Espin,Marco Demaria Book 2020 The Editor(s) (if applicable) and The Author(s), u

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书目名称Senolytics in Disease, Ageing and Longevity
编辑Daniel Muñoz-Espin,Marco Demaria
视频video
概述Reviews the brief history and rapid rise of senotherapeutics and senolytics in modern medicine.Describes additional avenues of research into senescence SASP and tissue engineering.Will benefit a broad
丛书名称Healthy Ageing and Longevity
图书封面Titlebook: Senolytics in Disease, Ageing and Longevity;  Daniel Muñoz-Espin,Marco Demaria Book 2020 The Editor(s) (if applicable) and The Author(s), u
描述.This book offers comprehensive information on the new and rapidly evolving science of identifying and targeting senescent cells, and on the exciting prospect of new diagnostic and therapeutic opportunities for stopping, and even reversing, the progression of disease and the deterioration of the human body due to ageing. .According to recent United Nations data, by 2050 one in six people worldwide will be older than age 65, with peaks rising to one in four people in Europe and North America. Remarkably, the number of persons aged 80 years or older is expected to triple, from 143 million in 2019 to 426 million in 2050. .First documented in the 1960s, the concept of cellular senescence as an underlying cause of ageing has been established in the course of the last decade. Using genetically engineered mouse models, researchers have demonstrated that the selective elimination of senescent cells can block and even reverse a number of age-related dysfunctions and pathologies, promoting both better health and longer life in the elderly. These include cardiovascular diseases; neurological disorders; type 1 and type 2 diabetes; inflammatory diseases; fibrosis; geriatric syndromes; chronic d
出版日期Book 2020
关键词Ageing; Regenerative Medicine; Cellular Senescence; Tissue Engineering; Senotherapies; Senoprobes; Preclin
版次1
doihttps://doi.org/10.1007/978-3-030-44903-2
isbn_softcover978-3-030-44905-6
isbn_ebook978-3-030-44903-2Series ISSN 2199-9007 Series E-ISSN 2199-9015
issn_series 2199-9007
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl
The information of publication is updating

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Potential Applications of Aptamers for Targeting Senescent Cells and specificity a wide range of cellular targets, including cell surface epitopes, thanks to their unique three-dimensional folding. Oligonucleotide aptamers have been widely applied for the discovery of biomarkers, since the early 1990s, and Affimers have recently emerged as valuable tools for bio
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Book 2020lls can block and even reverse a number of age-related dysfunctions and pathologies, promoting both better health and longer life in the elderly. These include cardiovascular diseases; neurological disorders; type 1 and type 2 diabetes; inflammatory diseases; fibrosis; geriatric syndromes; chronic d
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y in the early work of Russell and Moore is that their early incursions into philosophy were cultivated in this redoubtable neo-Hegelian atmosphere. Just before the turn of the century, however, Moore published ‘The Nature of Judgment’,. whose metaphysical doctrines had the unexpected effect of up-e
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Erin O. Wissler Gerdes,Yi Zhu,Tamar Tchkonia,James L. Kirklanddrew my attention to Thomas Aquinas’ ., which I had never read, having adopted, from the exposition in Anders Wedberg’s ., the opinion that, like Kant’s transcendental deduction, Aquinas’ demonstrations were ‘worthless’. However, the . was readily available on open shelves in the library at Nijmegen
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f Bolzano, Russell and Frege. The papers, whose authors include Per Martin-Löf, Göran Sundholm, Michael Della Rocca and Robin Rollinger, represent a finely judged editorial selection highlighting work on philosophers exercised by the question of whether or not an epistemic notion of judgement has a
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Qinghao Yu,Maximina H. Yunf Bolzano, Russell and Frege. The papers, whose authors include Per Martin-Löf, Göran Sundholm, Michael Della Rocca and Robin Rollinger, represent a finely judged editorial selection highlighting work on philosophers exercised by the question of whether or not an epistemic notion of judgement has a
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