书目名称 | Senolytics in Disease, Ageing and Longevity | 编辑 | Daniel Muñoz-Espin,Marco Demaria | 视频video | | 概述 | Reviews the brief history and rapid rise of senotherapeutics and senolytics in modern medicine.Describes additional avenues of research into senescence SASP and tissue engineering.Will benefit a broad | 丛书名称 | Healthy Ageing and Longevity | 图书封面 |  | 描述 | .This book offers comprehensive information on the new and rapidly evolving science of identifying and targeting senescent cells, and on the exciting prospect of new diagnostic and therapeutic opportunities for stopping, and even reversing, the progression of disease and the deterioration of the human body due to ageing. .According to recent United Nations data, by 2050 one in six people worldwide will be older than age 65, with peaks rising to one in four people in Europe and North America. Remarkably, the number of persons aged 80 years or older is expected to triple, from 143 million in 2019 to 426 million in 2050. .First documented in the 1960s, the concept of cellular senescence as an underlying cause of ageing has been established in the course of the last decade. Using genetically engineered mouse models, researchers have demonstrated that the selective elimination of senescent cells can block and even reverse a number of age-related dysfunctions and pathologies, promoting both better health and longer life in the elderly. These include cardiovascular diseases; neurological disorders; type 1 and type 2 diabetes; inflammatory diseases; fibrosis; geriatric syndromes; chronic d | 出版日期 | Book 2020 | 关键词 | Ageing; Regenerative Medicine; Cellular Senescence; Tissue Engineering; Senotherapies; Senoprobes; Preclin | 版次 | 1 | doi | https://doi.org/10.1007/978-3-030-44903-2 | isbn_softcover | 978-3-030-44905-6 | isbn_ebook | 978-3-030-44903-2Series ISSN 2199-9007 Series E-ISSN 2199-9015 | issn_series | 2199-9007 | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl |
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