Titlebook: Rat Genomics; G. Thomas Hayman,Jennifer R. Smith,Mary Shimoyama Book 2019 Springer Science+Business Media, LLC, part of Springer Nature 20

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Using Heterogeneous Stocks for Fine-Mapping Genetically Complex Traits,raits in mice and rats. We define an HS as an outbred population derived from an intercross between two or more inbred strains. HS have been used to perform genome-wide association studies (GWAS) for multiple behavioral, physiological, and gene expression traits. GWAS using HS require four key steps

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Mapping Mammary Tumor Traits in the Rat,rs that initiate after exposure to carcinogens or estrogens closely resemble the etiological, histopathological, and genomic features of human breast cancer. Recent developments in genome-editing techniques in the rat have also enabled the development of sophisticated models for identifying the gene

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Rat Models of Metabolic Syndrome,There are several rat models that encompass component features of MetS. Some models are inbred strains selected for one or more traits underlying MetS; others are population models with genetic risk for MetS traits, are induced by environmental stressors such as diet, are spontaneous monogenic mutan

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Genomic Research in Rat Models of Kidney Disease, disease or treat established kidney disease is limited. Investigating kidney disease directly in humans poses objective difficulties, which has led investigators to seek experimental animal models that simulate renal disease in humans. Animal models have thus become a tool of major importance in th

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Rat Models of Exercise for the Study of Complex Disease,opment of theoretically based and hypothesis-driven rat models that divide for both exercise capacity and numerous complex disease risks This rat model system was made by selectively breeding genetically heterogeneous rat populations for low and high performance on a speed ramped treadmill running t

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Behavioral Genetic Studies in Rats,c and biological research. Since the development of the first inbred rat strain in 1909, more than 700 unique inbred and outbred rat lines have been generated. Although rats have been somewhat eclipsed by mice in the last few decades, a renewed appreciation of the advantages of rats for behavioral a

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