Titlebook: Ras Superfamily Small G Proteins: Biology and Mechanisms 1; General Features, Si Alfred Wittinghofer Book 2014 Springer-Verlag Wien 2014 GT

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Targeting the Raf-MEK-ERK Mitogen-Activated Protein Kinase Cascade for the Treatment of , Mutant Canctivated protein kinase cascade the most intensively pursued. Presently, there are at least 33 inhibitors of this pathway under clinical evaluation. In this chapter, we provide a summary of this key Ras effector signaling network and the efforts to target the Raf-MEK-ERK cascade for the treatment of . mutant cancers.

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Atypical Rho Family Members14-3-3 proteins, and RhoBTB proteins can interact via their BTB domains with cullin-3, which is involved in proteasomal degradation. The proteins have been implicated in diverse functions, including cell adhesion and migration, vesicle trafficking and cell proliferation.

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Ras Superfamily Small G Proteins: Biology and Mechanisms 1978-3-7091-1806-1

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The Spatial Organization of Ras Signalingnding chaperones to maintain their spatial organization, we discuss the molecular components and opposed mechanisms of directional flux and diffusional randomization that partition Ras proteins on membranes. The pharmacological modulation of these spatially organizing systems can be exploited to aff

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Structure and Function of the mTOR Activator Rhebolysis. Further, an interaction between Tyr35 and the nucleotide inhibits GTP hydrolysis, and mutation of this residue resulted in a tenfold increase in the intrinsic GTPase activity of Rheb. The protein product of the Tsc2 gene (hamartin) was identified as a GTPase activating protein (GAP) that ina