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Titlebook: Ras Superfamily Small G Proteins: Biology and Mechanisms 1; General Features, Si Alfred Wittinghofer Book 2014 Springer-Verlag Wien 2014 GT

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Molecular Structures, Cellular Functions, and Physiological Roles of Rho Effectorso exerts its functions through downstream Rho effectors such as ROCK/Rho-kinase/ROK, mDia, Citron, PKN, Rhophilin, and Rhotekin. Our knowledge about the functions of Rho effectors has accumulated since their discoveries in the mid-1990s through in vitro studies using heterologous expression in cultu
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Ras Nanoclustersor Ras biological activity. Here we review the spatial organization of Ras proteins on the plasma membrane and discuss the molecular mechanisms that drive and potentially regulate this complex and dynamic nanoscale distribution.
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Evolution of the Ras Superfamily of GTPasests the history of the Ras superfamily including crucial evolutionary time points and detailed trees for the Rho, Ras, Rab, Arf, and Ran families. Based on this information we discuss some of the complex relationships between the evolution of proteins and the acquisition of distinctive cellular functions.
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