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Titlebook: Novel Inhibitors of Leukotrienes; Giancarlo Folco,Bengt Samuelsson,Robert C. Murphy Book 1999 Springer Basel AG 1999 asthma.cell.developme

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Leukotriene A4 hydrolase: A key enzyme in chemotactic leukotriene formation,ipid mediators exert a wide range of biological effects, for example activation of leukocytes and contraction of smooth muscles, particularly in the airways, and microcirculation. In the biosynthesis of leukotrienes, free arachidonic acid is converted by 5-lipoxygenase into 5(S)-.-5,6-oxido-7,9-.-11
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Metabolism of leukotrienes and formation of new leukotriene structures,gely in reduced or terminated biological activity, thus making metabolism a major process limiting leukotriene action . The majority of the enzymatic pathways involved in metabolic processing are common to a host of other endogenous biochemical substances, in particular eicosanoids such as prostagla
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