Titlebook: Novel Inhibitors of Leukotrienes; Giancarlo Folco,Bengt Samuelsson,Robert C. Murphy Book 1999 Springer Basel AG 1999 asthma.cell.developme

Preamble

Receptors for cysteinyl-leukotrienes: Targets for new drugs, as an antagonist of slow reacting substance of anaphylaxis (SRS-A) when it was not yet known that the latter was composed mainly of LTs [1]. Subsequently, the recognition of strict structural requirements for LT action [2, 3], their high potency (in the nM range) and the development of a number of

judiciousness

Targeted disruption of 5-lipoxygenase,as targeted gene inactivation, or in the common vernacular, gene knockout, has vaulted into the forefront of biology during the 1990s as the prime means to assess specific gene function [3, 4]. The technique involves cloning the murine gene of interest (or portion thereof), preparing a gene-targetin

CAMP

Transcellular biosynthesis of leukotrienes: A unique mode of cell communication, as well as of the enzymes involved in their synthesis. Leukotriene (LT) biosynthesis results from two different enzymatic processes: (i) a primary oxidation by 5-lipoxygenase (5-LO), a protein possessing a dioxygenase activity necessary for the synthesis of 5-hydroperoxyeicosatetraenoic acid (5-HPE

Canary

parasite

Entry rate and metabolic handling of LTC4 in the human circulation,se in patients with asthma and other disease states characterized by an inflammatory component. In this regard, urinary LTE. excretion rates have been extensively used over the last 5 years, following demonstration that the intravenous infusion [1–3] or inhalation [4] of LTC. is accompanied by dose-

constitute

Genetic polymorphisms of 5-LO,ons in the expression of 5-LO have important implications in the pathogenesis of diseases characterized by excess leukotriene production. In a clinical trial with zileuton about 50% of patients have shown a sustained improvement in FEV. (force expiratory volume at 1 sec) of ≥ 10% in response to 5-LO

Delectable

Leukotrienes and aspirin-intolerant asthma,his is a distinct clinical syndrome, called aspirin-induced asthma, or aspirin-intolerant asthma (AIA). It affects about 10% of adult patients with asthma, more often women than men, but is rare in asthmatic children [1–3].

plasma-cells

忘川河

Leukotrienes and allergic asthma,n asthma (Fig.1), the link between allergic asthma and leukotrienes is particularly strong. Thus, long before the identification of the leukotriene constituents of slow-reacting substance (SRS), it was evident that antigen challenge was an effective cause of the release of SRS from perfused animal l

barium-study

,The development of zafirlukast (Accolate®) and the Zeneca series of peptidyl-leukotriene receptor amed because they were first isolated from leukocytes and they have an unusual triene-containing chemical structure. The peptidyl-or cysteinyl-leukotrienes are a subclass that contains a peptide moiety attached to the leukotriene backbone. There are three major cysteinyl-leukotrienes — LTC., LTD. and