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Titlebook: Novel Inhibitors of Leukotrienes; Giancarlo Folco,Bengt Samuelsson,Robert C. Murphy Book 1999 Springer Basel AG 1999 asthma.cell.developme

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发表于 2025-3-21 16:25:42 | 显示全部楼层 |阅读模式
书目名称Novel Inhibitors of Leukotrienes
编辑Giancarlo Folco,Bengt Samuelsson,Robert C. Murphy
视频video
丛书名称Progress in Inflammation Research
图书封面Titlebook: Novel Inhibitors of Leukotrienes;  Giancarlo Folco,Bengt Samuelsson,Robert C. Murphy Book 1999 Springer Basel AG 1999 asthma.cell.developme
描述Many new antileukotriene drugs are now marketed as antiasthma drugs and represent the first new drugs in this field since the 1970s. This book covers the steps that have led to the discovery and development of these new drugs and offers detailed descriptions of their clinical applications. The review chapters on the main aspects of basic and applied leukotriene research are written by leading specialists in the field, and the volume takes a new approach in presenting information of particular interest to both scientists and clinicians in the fields of asthma, inflammation and allergic diseases.
出版日期Book 1999
关键词asthma; cell; development; diseases; drugs; inflammation; metabolism; pharmaceutical; research
版次1
doihttps://doi.org/10.1007/978-3-0348-8703-8
isbn_softcover978-3-0348-9736-5
isbn_ebook978-3-0348-8703-8Series ISSN 1422-7746 Series E-ISSN 2296-4525
issn_series 1422-7746
copyrightSpringer Basel AG 1999
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发表于 2025-3-21 21:06:08 | 显示全部楼层
,The development of zafirlukast (Accolate®) and the Zeneca series of peptidyl-leukotriene receptor a LrE.. Together they account for the biological activity of slow-reacting substance of anaphylaxis (SRS-A), which was discovered nearly 40 years ago when it was distinguished from histamine by its ability to produce a slowly developing and long-lasting contraction of isolated guinea pig ileum [2].
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1422-7746 es a new approach in presenting information of particular interest to both scientists and clinicians in the fields of asthma, inflammation and allergic diseases.978-3-0348-9736-5978-3-0348-8703-8Series ISSN 1422-7746 Series E-ISSN 2296-4525
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Metabolism of leukotrienes and formation of new leukotriene structures,pathways involved in metabolic processing are common to a host of other endogenous biochemical substances, in particular eicosanoids such as prostaglandins and thromboxanes. However, there are several enzymes rather specific for certain leukotrienes, suggesting a more unique role for such metabolic events mediated by these enzymes.
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The development of iralukast: A member of the Novartis series of cysteinyl leukotriene antagonists,lukast (AccolateTM, ICI 204,219) and montelukast (SingulairTM, MK 0476) are available on the market as treatment for asthma [1–6]. Further compounds, such as iralukast (CGP 45715A) are in development for this indication [7,8].
发表于 2025-3-23 06:50:15 | 显示全部楼层
Book 1999w chapters on the main aspects of basic and applied leukotriene research are written by leading specialists in the field, and the volume takes a new approach in presenting information of particular interest to both scientists and clinicians in the fields of asthma, inflammation and allergic diseases.
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