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Titlebook: Neuroprotective Signal Transduction; Mark P. Mattson Book 1998 Springer Science+Business Media New York 1998 Deprivation.Nervous System.Pa

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书目名称Neuroprotective Signal Transduction
编辑Mark P. Mattson
视频video
丛书名称Contemporary Neuroscience
图书封面Titlebook: Neuroprotective Signal Transduction;  Mark P. Mattson Book 1998 Springer Science+Business Media New York 1998 Deprivation.Nervous System.Pa
描述In Neuroprotective Signal Transduction prominent researchers and clinicians focus on how inter- and intracellular signaling mechanismsprevent the degeneration and death of neurons occurring in both acute and chronic neurodegenerative disorders. Authoritative contributions dissect the signaling pathways of an array of neuroprotective factors-ranging from neurotrophins (NGF, BDNF, NT-3, and NT-4/5), to growth factors (bFGF, IGF-1, GDNF), to cytokines (TNF, IL-1b, and TGFb), to secreted amyloid precursor proteins, to protease nexin-1. Also treated are cytoprotective signaling events that occur within injured neurons independently of intercellular signals.Neuroprotective Signal Transduction presents fundamental, cutting-edge treatment of the cellular and molecular signal transduction pathways found in human neurodegenerative conditions. The book‘s elucidation of the molecular cascades evolved by the nervous system to protect itself is now lead to effective strategies for preventing neuronal degeneration in such conditions as stroke, traumatic brain injury, Alzheimer‘s disease, Parkinson‘s disease, Huntington‘s disease, and amyotrophic lateral sclerosis, and will form the basis for powe
出版日期Book 1998
关键词Deprivation; Nervous System; Parkinson; cellular mechanisms; forebrain; genes; molecular mechanisms; neuron
版次1
doihttps://doi.org/10.1007/978-1-59259-475-7
isbn_softcover978-1-4757-5968-6
isbn_ebook978-1-59259-475-7
copyrightSpringer Science+Business Media New York 1998
The information of publication is updating

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Molecular Mechanisms of Neuroprotection from Neuronal Death by Trophic Factor Deprivation,populations losing >50% of all born neurons as a result of diverse developmental mechanisms (reviewed by Oppenheim, 1991). These mechanisms include the control of survival during precursor proliferation and differentiation through afferent innervation, and after target innervation by limited amounts
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Gene Induction and Neuronal Apoptosis,on neuronal apoptosis. In this chapter, we shall discuss the contribution of apoptosis to neuronal loss during development and during conditions of human pathology, an intracellular signaling cascade implicated as necessary for neuronal death in at least one model system, i.e., nerve growth factor (
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Clinical Potential of Compounds That Stimulate Nerve Growth Factor Production,GF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), NT-4/5, and NT-6, and their involvement in various processes in neuronal growth, differentiation, and maintenance has been clarified (Leibrock et al., 1989; Hohn et al., 1990; Maisonpierre et al., 1990; Hallbook et al., 1991; Gotz
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Neuroprotective Strategies Based on Interleukin Signaling,diators of inflammation. Cytokines form a network of interactive signals, some of which are stimulatory and others inhibitory. The physiologic roles of cytokines concern the coordination of processes between different cell types and the response to environmental stresses (Dinarello, 1996). With resp
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