Titlebook: Microbial Steroids; Methods and Protocol José-Luis Barredo,Ignacio Herráiz Book 2017 Springer Science+Business Media LLC 2017 Terpenoid lip

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Production and Biotransformation of Phytosterol Microdispersions to Produce 4-Androstene-3,17-Dionent technologies. However, the initial concentration of phytosterols in batch cultures is limited due to its low solubility in aqueous media, causing serious difficulties for scaling up because of the low mass transfer. In this chapter, we describe a fermentation method of a phytosterol microdispersi

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,β-Sitosterol Bioconversion to Androstenedione in Microtiter Plates,under similar conditions and replicate all functions of bench-scale reactors at dramatically smaller volumes. These plates, due to the standard footprint, can be integrated with liquid-handling systems and associated equipment expanding considerably their application and use. However, care has to be

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Keshan-disease

Scale-Up of Phytosterols Bioconversion into Androstenedione,nto steroid intermediates by removing the C17 side chain. This chapter shows the scale-up, from flask to fermentor, of the phytosterols bioconversion into 4-androstene-3,17-dione (androstenedione; AD) with . B-3805. Due to the fact that phytosterols and AD are nearly insoluble in water, two-phase sy

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Process for Biotransformation of Androsta-4-ene-3, 17-Dione (4-AD) to Androsta-1,4-Diene-3,17-Dioneone, estradiol, estriol and other related derivatives. De novo synthesis of this molecule is not yet reported in any form of living system, i.e., microbial, plant, and animal. The structural complexities due to presence of several chiral carbon centers create significant hurdles in chemical synthesi

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NOCT

,Obtaining of 11α-Hydroxyandrost-4-ene-3,17-dione from Natural Sterols,or obtaining 11α-hydroxyandrost-4-ene-3,17-dione (11α-HAD) from cheap and available natural sterols (phytosterols or cholesterol)..11α-HAD is a primary adrenal steroid in mammals and also a key precursor in the syntheses of halogenated corticoids. Conventional routes for its obtaining are based on c

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Steroid 11-Alpha-Hydroxylation by the Fungi , and ,, industries as a consequence of their physiological effects. Among their functions are anti-inflammatory, immunosuppressive, or contraceptive activities. Nowadays, microbial transformation of steroid precursors is winning relevance opposite to the chemical synthesis, since it allows for decreasing t

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