Titlebook: Lessons from Animal Diabetes VI; 75th Anniversary of Eleazar Shafrir Book 1996 Birkhäuser Boston 1996 Diabetes.Diabetes mellitus.genetics.

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BALK

Okamoto model for B-cell damage: Recent advanceshysiological and pathological significance of NAD. and poly (ADP-ribose) in pancreatic B-cells are discussed. In the second part, a novel metabolite of NAD., cyclic ADP-ribose, a second messenger for insulin secretion in B-cells, is described. Then, the synthesis and degradation of cyclic ADP-ribose

zonules

Alloxan derivatives as a tool for the elucidation of the mechanism of the diabetogenic action of alled to the property of the substance to stain the skin a characteristic red color.. Twenty years later, the German chemists, Wöhler and Liebig, studied uric acid oxidation in detail and obtained the same compound, which they named ., apparently from conflation of the words . and ... The early history

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Role of glucokinase in regulation of insulin secretion: Lessons from transgenic micew pancreatic B-cells to sense and respond to physiological changes in blood glucose. Glucose-induced insulin secretion requires the metabolism of glucose in B-cells,. and the phosphorylation of glucose to glucose-6-phosphate, which determines the rate of glycolysis, is considered the major glucose-s

复习

overhaul

Immunostimulatory versus immunosuppressive roles of IL-10 in IDDM: Analysis with IL-10—Producing tra. The models of human IDDM, non-obese diabetic (NOD) mice and Bio Breeding (BB) rats, have provided a large amount of information on the pathogenesis of IDDM. In these animal models, immune cells, which include helper T (CD4.) and cytotoxic T (CD8.) lymphocytes, B-lymphocytes, and macrophages, infil

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不近人情

Transgenic hyperinsulinemia: A mouse model of insulin resistance and glucose intolerance without obe primary metabolic abnormality initiating this disease process remains elusive, in spite of extensive study of the human condition and multiple animal models.. Most of these models share several features with human type II diabetes, including glucose intolerance associated with hyperinsulinemia, ins

Ointment

Spontaneously diabetic rat “OLETF” as a model for NIDDM in humans Charles River Canada (St. Constant, Quebec, Canada) in 1982. A strain of rats was developed by selective breeding from this rat and designated OLETF (Otsuka Long-Evans Tokushima Fatty). The OLETF line has been maintained since then by brother-sister mating at the Tokushima Research Institute, Otsuk