Titlebook: Leptin; Regulation and Clini Sam Dagogo-Jack, MD Book 2015 Springer International Publishing Switzerland 2015 Dysleptinemia.ELISA.Glucocort

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Sharon H. Chou M.D.,Christos Mantzoros M.D., D.Sc.ections representing the three main topics of this book. The solutions are also available as a PDF file and an MS Excel file and can be downloaded from .. For some of the questions, the answers are subject to interpretation and discussion, and therefore, answers might be adapted based on input from

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Leptin Receptors and Mechanism of Action,later with the identification of leptin and its receptor LepR. This was rapidly followed by the discovery of rare congenital leptin deficiency and mutations in . in subjects with strikingly similar early-onset and massive obesity phenotypes as in obese mutant mice. In this chapter, we describe sever

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Leptin Interaction with Brain Orexigenic and Anorexigenic Pathways,ng of the mechanisms underlying leptin’s anorexigenic actions in the brain is derived mainly from studies on rodents. Primary targets of leptin’s anorexigenic action are NPY/AGRP and POMC neurons in the hypothalamus and whose projections convey leptin signaling to regions of the brain that influence

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Measurement of Circulating Leptin and Soluble Leptin Receptors,riants of the leptin receptor gene, including an mRNA for a soluble leptin receptor, suggested the presence of a circulating leptin binding protein. It was subsequently demonstrated that leptin associated with a soluble leptin receptor binding protein, although the mechanism through which the solubl

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Physiological and Hormonal Factors that Influence Leptin Production,siological, cellular, and molecular processes across diverse organ systems. This chapter discusses the physiological, hormonal, and metabolic factors involved in the synthesis and secretion of leptin and the regulation of circulating leptin levels in humans. Although leptin secretion was rarely meas