| 书目名称 | Leptin | | 副标题 | Regulation and Clini | | 编辑 | Sam Dagogo-Jack, MD | | 视频video | | | 概述 | Emphasizes metabolic pathophysiology and clinical applications of leptin in humans.Presents therapeutic trials of recombinant leptin replacement in humans for a variety of disorders.Considers the futu | | 图书封面 |  | | 描述 | .Twenty years after its discovery, recombinant human leptin has been approved by the Food and Drug Administration for the treatment of patients with lipodystrophy. Beginning with a synthesis of the vast body of work on its discovery, dissection of mechanisms, and effects in experimental models , the focus of this book shifts to a consideration of the regulation and role of leptin in humans. The emphasis on human-level data is a unique feature of this book. The results of numerous studies indicate that leptin is indeed a regulated human hormone..Leptin .provides a detailed account of the myriad physiological, hormonal, metabolic, immunological, mitogenic and inflammatory modulators and targets of leptin in a single volume. Next follows a comprehensive presentation of the therapeutic trials of recombinant leptin in patients with congenital leptin deficiency, lipodystrophy, hypothalamic amenorrhea, and other emerging areas, including leptin supplementation in leptin-replete subjects, leptin substitution for insulin in diabetic models, and novel combination regimens of leptin and other biogenic peptides. Unanswered questions and future directions in leptin research are highlighted in t | | 出版日期 | Book 2015 | | 关键词 | Dysleptinemia; ELISA; Glucocorticoids; Homeostasis; Hormonal regulation; Hypertension; Hypothalamus; Leptin | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-319-09915-6 | | isbn_softcover | 978-3-319-35413-2 | | isbn_ebook | 978-3-319-09915-6 | | copyright | Springer International Publishing Switzerland 2015 |
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发表于 2025-3-21 18:36:00
