Titlebook: Isolation and Molecular Characterization of Circulating Tumor Cells; Mark Jesus M. Magbanua,John W. Park Book 2017 The Editor(s) (if appli

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Mark Jesus M. Magbanua,John W. ParkInformative and authoritative, this book presents state-of-the-art strategies for CTC research from experts and key opinion leaders in the field.This book contains creative and innovative ideas for ra

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978-3-319-85787-9The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl

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Isolation and Molecular Characterization of Circulating Tumor Cells978-3-319-55947-6Series ISSN 0065-2598 Series E-ISSN 2214-8019

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Detection and Enumeration of Circulating Tumor Cells with Invasive Phenotype,rcome these difficulties, novel techniques have been developed to detect and enumerate CTCs with an invasive phenotype. In this chapter, we will summarize these recently developed methods and detail two novel methods for capturing and enriching CTCs on the basis of their viability and their invasive properties.

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Book 2017eatment and inferior survival probabilities. Despite this clinical significance, the molecular biology of CTCs remains poorly understood. The paucity in molecular information can be attributed to the tremendous technical challenges involved in isolating these extremely rare cells. Recent technologic

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Expression of Epithelial Mesenchymal Transition and Cancer Stem Cell Markers in Circulating Tumor Cd in EMT- or stem-cell-like CTC. Both for CTCs with EMT- or stem-cell features different markers have been proposed. However, there is still a lack of evidence on the association of these markers with functional features and characteristics for stem cells and cells undergoing EMT.

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Glycan Markers as Potential Immunological Targets in Circulating Tumor Cells,formance in CTC-detection and immunotyping analysis. In this article, identifying breast CTC-specific glycan markers and targeting mAbs serve as examples to illustrate this tumor biomarker discovery strategy.