Titlebook: Isolation and Molecular Characterization of Circulating Tumor Cells; Mark Jesus M. Magbanua,John W. Park Book 2017 The Editor(s) (if appli

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Personalized Treatment Through Detection and Monitoring of Genetic Aberrations in Single Circulatin most widespread in the world and is difficult to target because of its complex nature, challenges in getting quality samples and dynamic temporal changes in response to treatment. Conventional methods of detection and monitoring the disease profile do not suffice to be able to target the heterogene

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Glycan Markers as Potential Immunological Targets in Circulating Tumor Cells,e likely targetable in immunotherapy against tumor metastasis. Using carbohydrate microarrays, anti-tumor monoclonal antibodies (mAbs) were scanned against a large panel of carbohydrate antigens to identify potential tumor glycan markers. Subsequently, flow cytometry and fiber-optic array scanning t

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Significance of EGFR Expression in Circulating Tumor Cells,le in cancer progression, genetic changes related to metastasis, and resistance to treatment. The aberrant behavior of cancer cells is caused by genetic mutations and altered patterns of gene expression. These changes can be responsible for an increase in cell motility but also an ability of CTCs to

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Circulating Tumor Cells as Cancer Biomarkers in the Clinic, understanding the process of metastasis. The analysis of CTCs during the early stages, as a “liquid biopsy,” helps to monitor patients at different points in the disease course, including minimal residual disease, providing valuable information about the very early assessment of treatment effective

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Strategies for Isolation and Molecular Profiling of Circulating Tumor Cells,ation of CTCs early in the progression of cancer may reveal targets for initial cancer detection and for anti-cancer treatment. This chapter will evaluate strategies and devices used for the isolation and identification of CTCs directly from clinical samples of blood. Recent progress in the understa

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Aptamer-Based Methods for Detection of Circulating Tumor Cells and Their Potential for Personalizedat the aptamers are selected for cell surface biomarkers in their native state, and conformation without previous knowledge of their biomarkers. Once aptamers are produced, they can be used to identify CTC biomarkers using mass spectrometry. The biomarkers and corresponding aptamers can be exploited

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