| 书目名称 | Innate Tolerance in the CNS | | 副标题 | Translational Neurop | | 编辑 | Jeffrey M. Gidday,Miguel A. Perez-Pinzon,John H. Z | | 视频video | | | 概述 | This book will be the first to summarize basic mechanisms of both pre- and post-conditioning..Expand the basic science studies to date for their potential application as a clinical treatment..Critical | | 丛书名称 | Springer Series in Translational Stroke Research | | 图书封面 |  | | 描述 | Cerebral preconditioning is a phenomenon wherein a mild insult or stress induces cellular and tissue adaptation or tolerance to a later, severe injury, therefore reflecting the efficacy of endogenous mechanisms of cerebrovascular protection. Initially identified for rapid cardiac protection, preconditioning has expanded to all aspects of CNS protection from ischemia, trauma and potentially neurodegeneration. Many different stimuli or stressors have been identified as preconditioning agents, suggesting a downstream convergence of mechanisms and underscoring the potential for translational application of preconditioning in the clinic. Moreover, the fundamental mechanisms responsible for preconditioning-induced tolerance will help in the design novel pharmacological approaches for neuroprotection. While stroke and many other brain injuries are not predictable, in some populations (e.g., metabolic syndrome, patients undergoing carotid endarterectomy, aneurysm clipping, or with recent TIAs) the risk for stroke is identifiable and significant, and preconditioning may represent a useful strategy for neuroprotection. For unpredictable injuries, post-conditioning the brain – or inducing end | | 出版日期 | Book 2013 | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4419-9695-4 | | isbn_softcover | 978-1-4939-4177-3 | | isbn_ebook | 978-1-4419-9695-4Series ISSN 2363-958X Series E-ISSN 2363-9598 | | issn_series | 2363-958X | | copyright | Springer Science+Business Media New York 2013 |
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发表于 2025-3-21 17:46:28
