Titlebook: Innate Tolerance in the CNS; Translational Neurop Jeffrey M. Gidday,Miguel A. Perez-Pinzon,John H. Z Book 2013 Springer Science+Business Me

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Hibernation: A Natural Model of Tolerance to Cerebral Ischemia/Reperfusiononged torpor where whole body metabolic rate, core body temperature (..), heart rate, and blood flow decrease to 1–10 % of values observed during sleep. These bouts of torpor are interrupted at regular intervals by brief episodes of heterogeneous rewarming and reperfusion of vital organs, including

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Neuroprotection and Physical Preconditioning: Exercise, Hypothermia, and Hyperthermia. Despite their differences, these varying physical stimuli provide different value in terms of potential clinical utility. This chapter reviews the features and mechanisms underlying the cerebral protection that is conferred through the utilization of exercise, hypothermia, and hyperthermia. The ne

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A New Future in Brain Preconditioning Based on Nutraceuticals: A Focus on α-Linolenic Omega-3 Fatty paucity of treatments. The only currently clinically approved treatment is recombinant tissue plasminogen activator to restore cerebral blood flow, but eligibility requirements restrict this treatment to approximately 5 % of patients. Unfortunately, therapeutics designed to provide direct neuroprote

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Surgical Methods to Induce Brain Preconditioningn someone approaches this field of research, the most intuitive method that comes into the researcher’s mind to induce preconditioning is to use a short subliminal occlusion of the artery that will undergo subsequent harmful occlusion. Despite the relatively simpleness of the idea, the definition of

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Tolerance Against Global Cerebral Ischemia: Experimental Strategies, Mechanisms, and Clinical Applic which would otherwise have been lethal. The focus of this chapter is to provide a comprehensive review of the literature on IPC in animal models of global cerebral ischemia. Major mechanisms of ischemia tolerance and the clinical importance of IPC mimetics and adaptations in animals that tolerate i

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