Titlebook: Immuno-Psychiatry; Facts and Prospects Michael Berk,Marion Leboyer,Iris E. Sommer Book 2021 Springer Nature Switzerland AG 2021 Immunology.

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Pro-inflammatory Cytokines and the Depressive Phenotypesms whereby such inflammatory changes lead to aberrant endocrine and neurotransmitter functions are also outlined and implicate the pro-inflammatory cytokines which are released from activated microglia as the primary cause in brain structure and function. It is now apparent that the inflammasome co

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Human Endogenous Retrovirus as Missing Link in the Global Etiopathogenesis of Schizophrenia and Biporly understood. This review explains how human endogenous retroviruses (HERVs) may provide a missing link between environmental factors, genomics, and pathogenic pathways leading to clinical expression. HERVs represent a disregarded part of the human genome resulting from endogenization of retroviru

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The Human Leukocyte Antigen System in Psychiatry: Where Do We Stand?gulation of immune/inflammatory processes and the dysfunctional system could lead to a variety of (auto) immuno-inflammatory disorders ranging from infection to cancer. Also given their role in neurodevelopment and neuroplasticity, especially through regulation of microglial activation and synaptic

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Testable Hypotheses Relating Complement Pathways to Elevated Risk for Schizophrenia Large-scale genome-wide association studies (GWAS) have revealed risk attributable to over 170 genomic loci, with varied effect sizes. Statistically, the most significant risk locus maps to the major histocompatibility complex (MHC) region on chromosome 6 (odds ratio ~1.28). One of the associated M

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Is Autism Spectrum Disorder Related to Immune Dysfunction(s)? well as restricted patterns of interest or behavior. On top of genetic and environmental risk factors, various immuno-inflammatory processes have been associated with ASD, at all developmental stages raising hopes of the possibility of identifying homogenous subgroups and of innovative diagnostic s

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