Titlebook: Immuno-Psychiatry; Facts and Prospects Michael Berk,Marion Leboyer,Iris E. Sommer Book 2021 Springer Nature Switzerland AG 2021 Immunology.

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The Aberrant Immune System in Bipolar Disorderh for new therapy options. The chapter follows the macrophage-T cell theory of mood disorders formulated in the 1990s. The theory was founded on finding high serum levels of pro-inflammatory and T cell regulating cytokines in mood disorder patients. Besides higher levels of pro-inflammatory cytokine

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Inflammation and Depression: Is Immunometabolism the Missing Link?epression is characterized by a predominance of somatic symptoms over cognitive and affective symptoms of depression. The possibility of a causal role of inflammation in these symptoms has been investigated mainly in terms of interaction between inflammatory mediators and brain neurotransmitter meta

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Autoimmune Diseases and Infections as Risk Factors for Mental Disordersons regarding the risk of development of mental disorders, and risks of mental disorders are further increased with the temporal proximity of the diagnosis, and if causal, it could show to be important risk factors for mental disorders. Future longitudinal studies are needed with measurements from m

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The Life-Long Consequences of Prenatal and Childhood Stress on the Innate and Adaptive Immune System-5 and IL-13. Regarding childhood stress, IL-6 was generally increased and changes in C-reactive protein (CRP) were detected after childhood trauma most consistently in the middle-aged and elderly populations. The adaptive immune system showed a dampened activity, marked by T lymphocyte senescence a

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Immunity as a Common Risk Pathway for Psychiatric and Medical Comorbiditysorders in a given individual. These effects are most pronounced in severe mental illnesses such as schizophrenia, bipolar disorder and severe treatment-resistant depression, with highest rates of medical comorbidity and multimorbidity. The pathways underlying comorbidity are complex with many mecha

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Cytokines as Biomarkers in Psychiatric Disorders: Methodological Issuese used in clinical settings. Here, we will argue that this failure may have been due at least in part to overlooked methodological issues not only for preparation, storage, and analysis of the biological samples but also for statistical analysis of the datasets. We will also propose some guidelines