Titlebook: Humanized Mice for HIV Research; Larisa Y. Poluektova,J. Victor Garcia,Andrew M. Ta Book 2014 Springer Science+Business Media New York 201

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Book 2014en made in the development, improvement, implementation, and validation of humanized mouse models. The first two parts of this book cover the basics of human-to-mouse xenotransplantation biology, and provide critical information about human immune cell development and function based on individual mo

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Larisa Y. Poluektova,J. Victor Garcia,Andrew M. TaFeatures mouse-to-human xenotransplantation/cross-reactivity of immune systems.Assesses the applicability of different mouse genetic backgrounds for humanization and human immune system function.Writt

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Humanized Mice as Models for Human Diseaseue applications for discovery research and preclinical analysis of antiviral drugs. In this review, we strive to place this continuum of work into perspective, both to provide an historical footing to its progress and to urge attention to obstacles that continue to confront the full application of these models to the analysis of human disease.

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978-1-4939-4563-4Springer Science+Business Media New York 2014

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Role of Mouse Innate Immunity in Immunodeficient Mice for Xenotransplantationmunodeficient mice and their improvement have contributed greatly to the evolution of xenograft animal models. In the 1990s, C.B-17-. or NOD-. mice, which lack T and B lymphocytes, were used as standard xenograft models. However, engraftment of xenografts in these mice was inefficient because innate

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