Titlebook: Humanized Mice for HIV Research; Larisa Y. Poluektova,J. Victor Garcia,Andrew M. Ta Book 2014 Springer Science+Business Media New York 201

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Biology of Human Hematopoietic Stem Cell Xenotransplantation in Micephoid cells. The failure of hematopoietic stem cell transplantation across species can be caused not only by immune rejection but also by the unfavorable hematopoietic microenvironment in a xenogeneic recipient. The use of currently available immunodeficient mice can prevent xenograft rejection by T

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BM Hematopoietic Niche Occupancy Defect of HSC in , Micef human hematopoietic stem cell (HSC)/(HPC) into these host mice provides long-term multilineage hematopoiesis and generation of human immune responses against a variety of antigens including HIV..Development of such mice has been mainly based on the recombination activating genes 1 and 2 (. and .)

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Human T-Cell Biology in a Mouse Environment have been obtained. Although these new humanized mouse models represent a major achievement, they still exhibit several limitations and do not fully support optimal human leukocyte biology. Still, they provide clues on what could be the milestones to target for the next generation of humanized mous

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