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Titlebook: Heart rate as a determinant of cardiac function; Basic mechanisms and G. Hasenfuss,H. Just Conference proceedings 2000 Steinkopff Verlag Da

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Adrenergic regulation of the force-frequency effecttly been identified. The effect of ß-AR stimulation to amplify the force-frequency effect is responsible for a large component of the positive inotropic effect of exercise in conscious dogs and also can be demonstrated at rest with dobutamine infusions over a range of paced heart rates. The interact
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Force-frequency relation in patients with left ventricular hypertrophy and failurehamber compliance, delayed relaxation, and small and often deformed cavities all conspire to limit pump performance and reserve capacity while raising pulmonary venous pressures. Typically, patients have supranormal rest systolic function, intracavitary pressure gradients, dynamic obstruction, and e
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Rate-dependence of antiarrhythmic and proarrhythmic properties of class I and class III antiarrhythmnce of class I drugs (i.e., increasing blockade of fast Na.-channels with faster rates) results from periodical drug binding to Na.-channel sites which are preferably available in the activated and/or inactivated channel states (use-dependence). With respect to their binding and unbinding kinetics,
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Left ventricular restoring forces: Modulation by heart rate and contractilitye nonfilling diastoles during which the LV fully relaxed at its end-systolic volume (ESV). Restoring forces (RFs) generated during contraction which result in LV filling by suction were considered to be present when the fully relaxed pressure (FRP) was negative. We characterized RFs in terms of the
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978-3-642-47072-1Steinkopff Verlag Darmstadt 2000
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