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Factors that affect regulation of cGMP synthesis in vertebrate photoreceptors and their genetic lintified in rods and cones that are regulated by Ca.-binding proteins, GCAPs. At low intracellular concentrations of Ca.typical for light-adapted rods and cones GCAPs activate RetGC, but concentrations above 500 nM typical for dark-adapted photoreceptors turn them into inhibitors of retGC. A variety o

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Anticlimax

The receptor-like properties of Nitric oxide-activated soluble guanylyl cyclase in intact cells,n its natural environment, within cells, has revealed several key differences. For example, the enzyme exhibits a rapidly desensitizing profile of activity; the potency of NO is 45 nM for the minimally-desensitized enzyme but becomes higher with time; deactivation of sGC on removal of NO is 25-fold

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不能妥协

Natriuretic peptide receptor: Structure and signaling,hat share a common overall molecular configuration. Collectively, theses GCase-coupled receptors belong to a larger family of single-transmembrane sequence receptors that include growth hormone and cytokine receptors. The signal transduction mechanism of these receptors has not been thoroughly under

织布机

Intracellular trafficking and metabolic turnover of ligand-bound guanylyl cyclase/atrial natriuretiant and antiproliferative effects, important factors in the control of blood pressure homeostasis. One of the principal loci involved in the regulatory action of ANP is the guanylyl cyclase-linked ANP-receptor which has been designated as NPRA, also referred to as GC-A, whose ANP-binding efficiency

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