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Aleksandra Bogdanovic,Dejan Skalah. In normal adult tissues, these rates are balanced such that a steady state (i.e., self-renewing) relationship is maintained in which the size of the normal tissue does not increase continuously with time. Studies in a variety of different tissues have demonstrated that this steady state balance i
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James R. Ehleringer,Curtis Clarkine epithelial cells must double within two days and return to normal levels in the next two. This process is repeated throughout the reproductive lifetime of the animal, which means that the murine uterine epithelium will be reconstituted approximately 90 times in one year. This remarkable growth p
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https://doi.org/10.1007/978-3-642-29119-7diated by estrogen and progesterone (again under pituitary control) (2). In rodent models of carcinogen-induced breast cancer, it has been shown that both progesterone and estrogen seem to be required for tumor formation and for early growth of tumors (3–4). Presumably, the mechanism of interaction
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James R. Ehleringer,Curtis Clark, the estrogen receptor (ER), functioning as a transcription factor, is involved in regulation of expression of specific genes, some of which may be involved in estrogen-induced mitogenesis; these pathways, however, remain to be established. At the same time, results have been presented that raise t
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