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Growth Factors Affecting Normal and Malignant Prostatic Cellsh. In normal adult tissues, these rates are balanced such that a steady state (i.e., self-renewing) relationship is maintained in which the size of the normal tissue does not increase continuously with time. Studies in a variety of different tissues have demonstrated that this steady state balance i
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Estrogens and Growth Factors in the Development, Growth, and Function of the Female Reproductive Traine epithelial cells must double within two days and return to normal levels in the next two. This process is repeated throughout the reproductive lifetime of the animal, which means that the murine uterine epithelium will be reconstituted approximately 90 times in one year. This remarkable growth p
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Drugs Containing Pungent Principles,is, therefore, a regulatory molecule capable of affecting the same cell types, including epithelial cells, that respond to EGF (2). Transforming growth factor βs (TGFβs), on the other hand, are 25-kD peptides consisting of two identical 112-amino acid subunits that are synthesized as part of a large
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Renu Khanna-Chopra,Vimal Kumar Semwald through binding to a transmembrane receptor glycoprotein (EGFR) composed of an extracellular EGF-binding domain, a transmembrane segment, and an intracellular domain that has tyrosine kinase activity (1). The EGFR has been subject to intense study in relation to cancer biology because of its homol
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Monika Patel,Asha Kumari,Asish Kumar Paridantification of systemic mammogens, notably the ovarian steroids, pituitary peptides, adrenal corticoids, and placental factors (1). The distinguishing feature of these hormones is that they all drive mammary development towards growth or functional differentiation; that is, they act as positive regu
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