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Dilip Kumar Chakrabarti,Prabhat Mittalnsformation of normal fibroblasts in culture (3). The designation “α” distinguishes this molecule from TGFβ, a completely unrelated polypeptide that cooperates to enhance the TGFα-induced, anchorage-independent growth of normal fibroblasts in a soft agar assay (4).

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EGF-Mediated Growth Control and Signal Transduction in the MDA-MB-468 Human Breast Cancer Cell Lined through binding to a transmembrane receptor glycoprotein (EGFR) composed of an extracellular EGF-binding domain, a transmembrane segment, and an intracellular domain that has tyrosine kinase activity (1). The EGFR has been subject to intense study in relation to cancer biology because of its homol

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