Titlebook: Genotoxicity Assessment; Methods and Protocol Alok Dhawan,Mahima Bajpayee Book 2019Latest edition Springer Science+Business Media, LLC, par

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https://doi.org/10.1007/978-3-663-06775-7detection of chromosomal damage (fragments or whole chromosome) in interphase, the micronucleus test can be used, and a description of this test is also presented. Criteria for determining a positive result using appropriate statistical methods are described.

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https://doi.org/10.1007/978-3-322-98858-4errations may either be induced in vivo by environmental or occupational influences or in vitro after experimentally controlled manipulations in order to detect or to test the mutagenic potency of various agents.

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Alok Dhawan,Mahima BajpayeeIncludes cutting-edge techniques.Provides step-by-step detail essential for reproducible results.Contains key implementation advice from the experts

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https://doi.org/10.1007/978-1-4939-9646-9Genetic toxicology; Mutation assays; DNA damage; Chromosomal abnormalities; Toxicogenomics; Computational

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https://doi.org/10.1007/978-94-017-6558-9ymidine kinase (.) locus of the L5178Y (. −3.7.2C) cell line derived from a mouse thymic lymphoma. This assay is capable of detecting a wide range of genetic events including point mutations, deletions and multilocus, chromosomal rearrangements, mitotic recombination and nondisjunction. There are tw

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https://doi.org/10.1007/978-3-663-06775-7ls used for detection of chromosomal aberrations induced by genotoxic agents in vitro both in the presence or absence of rat liver-derived metabolizing systems are given in this chapter. Structural chromosomal aberrations that can be observed and quantified at metaphases are described here. For the