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Titlebook: Genomics, Personalized Medicine and Oral Disease; Stephen T. Sonis, DMD, DMSc Book 2015 Springer International Publishing Switzerland 2015

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Gene Therapy for Xerostomia, life disorders that lack a suitable treatment, has become accepted. This chapter describes the development of a gene therapy for one such quality of life disorder, the xerostomia caused by radiation-induced salivary gland hypofunction, from its initial idea to the conduct of a first in-human clinical trial.
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Bisphosphonate Related Osteonecrosis of the Jaw,study of cases and controls, describe its main methods and attributes, and main results. RBMS3 and several other genetic markers of susceptibility have been identified and are currently undergoing further evaluation in an independent cohort of osteonecrosis patients and exposed controls.
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Personalized Medicine, Genomics and Oral Diseases: The Future,on the ClinTrials.gov database had pharmacogenomics outcomes. Clearly we have a ways to go. This chapter focuses on both the potential and the challenges associated with the translation of genomics to the clinic.
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