Titlebook: Genomics, Personalized Medicine and Oral Disease; Stephen T. Sonis, DMD, DMSc Book 2015 Springer International Publishing Switzerland 2015

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The Oral Microbiome and Its Relationship to Genomics and Oral Disease,dual variations remain to be sorted out, significant progress in understanding the role of the microbiome in disease has been made. Improved technologies and bioinformatics tools are now available to characterize the oral microbiome, in terms of type and distribution of species, gene enrichments and

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,Developmental Anomalies – Clefts,plying the promise of personalized medicine for OFCs and other developmental anomalies. Notably, OFC represents a major success in applying genome-wide approaches to the etiology of a complex trait, and is poised for further breakthroughs in the near future.

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Caries,r, our goal is to review the human genetics and genomics literature with an emphasis on the areas that may impact the clinical application of the personalized medicine model for the prevention or treatment of dental caries.

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Periodontal Disease,ted to a few loci, most importantly .., . and ., which gave evidence of disease relevance by statistically significant associations and replication in large homogenous study populations. These genes are largely located in regulatory networks that integrate interactions of the metabolic and immune sy

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Aphthous Stomatitis,ndividual. This hinders the precise identification of the reasons and the establishment of a unique therapeutic protocol, which functions in all cases. In this scenario, the application of personalized medicine will be of fundamental importance. Knowledge of the altered signaling pathways associated

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Lichen Planus,g several databases until the identification of a final set of genes. Interactions among these genes were mapped and given a significance score using STRING database. For each gene, significance scores were summed to obtain a weighted number of links (WNL) and subsequently genes were clustered accor

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Gene Therapy for Mucositis,on of MnSOD-PL to patients twice a week during chemoradiotherapy of lung cancer has demonstrated significant protection of the esophagus in patients, who swallow MnSOD-PL. A “mouthwash” administration of MnSOD-PL is being tested in a clinical trial at the University of Pittsburgh Cancer Institute. R