Titlebook: Genomic Adaptability in Somatic Cell Specialization; Marie A. DiBerardino,Laurence D. Etkin Book 1989 Springer Science+Business Media New

Oafishness

Making Global Partnership Work, generally based on modifications at the level of DNA. Five kinds of modifications are known: (1) elimination of DNA sequences; (2) amplification of selected sequences; (3) rearrangement of DNA segments, with no loss or gain of sequence; (4) methylation of DNA; and (5) changes in transcriptional activity of DNA mediated by transcription factors.

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: a Mycelial, Spore-Bearing Prokaryotederable amount of interest. This chapter reviews experiments that have demonstrated the complementary roles of the two parental genomes in the mouse, thus establishing the existence of genomic imprinting in murine development. Also, we indicate some of the approaches being employed to elucidate the molecular basis of this phenomenon.

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https://doi.org/10.1057/9781137397881e differentiated state. It is now widely accepted that the process and stability of cell specialization are under genetic control. But the frequency and extent to which this genetic control involves irreversible genetic changes among eukaryotic animals remain unanswered.

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Book 1989­ tors in the study of genomic adaptability. lowe a special debt of gratitude to Dr. Marie A. DiBerardino, who developed the concept of the volume. Dr. DiBerar­ dino is also a very active member of the editorial board for this series. Much of the success of this series is due to her valuable advice.

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Introduction Early Development and Cell Commitment,, there is increasing cellular diversity, yielding a multitude of cell-specific phe- notypes. Cells become different from one another, and their developmental potential is progressively restricted. The determined state and the overtly differentiated state are exceedingly stable and heritable during

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Fate and Nuclear Localization of Germinal Vesicle Proteins during Embryogenesis,The fertilized egg cleaves rapidly to form a blastula without a significant expression of the embryonic genes during the first 12 cell cycles and without net intake of food during the first several days. The resources required for fast autonomous embryogenesis are accumulated during the several mont

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Genomic Imprinting in the Mouse,s only recently that the functional nonequivalence of the maternal and paternal genomes has been established conclusively and so has commanded a considerable amount of interest. This chapter reviews experiments that have demonstrated the complementary roles of the two parental genomes in the mouse,

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Phenotypic Changes in Cell Culture,ental products, each of these carries a spectrum of identifying markers: distinctive patterns of enzyme activities or unique metabolic products, diagnostic cytoarchitecture or elements of fine structure, and other specificities recognizable microscopically or biochemically. Phenotypic changes in ear