Titlebook: Genome Stability and Human Diseases; Heinz-Peter Nasheuer Book 2010 Springer Science+Business Media B.V. 2010 Chromosom.DNA.Viruses.genes.

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Core and Linker Histone Modifications Involved in the DNA Damage Response, as such, are particularly important in the early stages of the DNA damage response. This review will focus on such modifications, the enzymes responsible and also highlights their importance by reporting known roles for these modifications in genome stability and disease.

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Structure and Function of Histone H2AX, Furthermore, the biochemical properties of H2AX protein within the nucleosome structure and its distribution within chromatin also point to features linked to its role in the DNA damage response. In particular, the theoretical inter-nucleosomal spacing of H2AX and the potential implications of amin

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Centromeres: Assembling and Propagating Epigenetic Function,d centromeres themselves are determined by their unique protein composition. Apart from budding yeast, centromeres are not specified simply by DNA sequence, but rather through chromatin composition and architecture and are thus epigenetically determined. Centromeres are built on a specific nucleosom

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Nonhomologous DNA End Joining (NHEJ) and Chromosomal Translocations in Humans,se μ (Pol μ), DNA polymerase . (Pol .), XLF (also called Cernunnos), XRCC4, and DNA ligase IV. These enzymes constitute what some call the classical NHEJ pathway, and in wild type cells, the vast majority of joining events appear to proceed using these components. NHEJ is present in many prokaryotes

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