| 书目名称 | Genome Stability and Human Diseases | | 编辑 | Heinz-Peter Nasheuer | | 视频video | | | 概述 | Discusses cancer cell biology in relation to Genome stability and Cell cycle regulation.Unique assembly of experts in these fields who wrote a comprehensive and deep up-to-date overview.Discusses mode | | 丛书名称 | Subcellular Biochemistry | | 图书封面 |  | | 描述 | .Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our fundamental principles of understanding tumourigenesis: It thought that cancer arises from the sequential acquisition of genetic alterations in specific genes. In this hypothesis, these rare genetic events represent rate-limiting ‘bottlenecks’ in the clonal evolution of a cancer, and pre-cancerous cells can evolve into neoplastic cells through the acquisition of somatic mutations...This book is written by international leading scientists in the field of genome stability. Chapters are devoted to genome stability and anti-cancer drug targets, histone modifications, chromatin factors, DNA repair, apoptosis and many other key areas of research. The c | | 出版日期 | Book 2010 | | 关键词 | Chromosom; DNA; Viruses; genes; genetic disorders; proteins; regulation; cytogenetics | | 版次 | 1 | | doi | https://doi.org/10.1007/978-90-481-3471-7 | | isbn_softcover | 978-94-007-3125-7 | | isbn_ebook | 978-90-481-3471-7Series ISSN 0306-0225 Series E-ISSN 2542-8810 | | issn_series | 0306-0225 | | copyright | Springer Science+Business Media B.V. 2010 |
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发表于 2025-3-21 18:36:02
