Titlebook: Genetics of Male Infertility; A Case-Based Guide f Mohamed Arafa,Haitham Elbardisi,Ashok Agarwal Book 2020 Springer Nature Switzerland AG 2

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Genetic Basis of Sperm Morphologic Defects: Head Defects and Body and Tail Defectsell as clinicians. Among multifactorial aetiology which contributes to male infertility, genetic abnormalities play an important role of risk factor and cannot be ignored. Therefore, recognising and understanding how genetic abnormalities influence male infertility is the foremost agenda of most res

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Sperm DNA Fragmentation and Male Infertilityination status determine the extent of DNA damage. Oxidative stress due to increased levels of reactive oxygen species in the seminal fluid damages sperm DNA. Several tests have been introduced into the clinical laboratory settings to assess the sperm chromatin integrity and the extent of SDF. This

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Chromosomal Translocations and Inversion in Male Infertility of chromosomal abnormalities. An array of functional gene expressions determines normal testicular development and robust spermatogenesis. In case of any anomalies in these genes, testicular dysgenesis as well as spermatogenic arrest may occur leading to a comprised state of male fertility. The pre

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Infertility and Cryptorchidismwall to the scrotum. It is one of the most frequent congenital birth defects in male children and represents an important risk factor for infertility and testicular cancer. Approximately 2–4% of full-term newborns are born with at least one cryptorchid testis. In preterm births, the rate increases t

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Kartagener and Immotile Cilia Syndromemong its genetic causes and deserves special attention, as it is accompanied by many complications that may severely affect the patient’s quality of life. PCD was first reported by Kartagener in 1933, when they described four patients presenting with the triad of chronic sinusitis, bronchiectasis, a