Titlebook: Genetics of Male Infertility; A Case-Based Guide f Mohamed Arafa,Haitham Elbardisi,Ashok Agarwal Book 2020 Springer Nature Switzerland AG 2

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https://doi.org/10.1007/978-3-662-63618-3e of cilia, an abnormal ciliary structure may lead to the reduction or inability of the flagellum to adequately work; as a consequence, male infertility may occur. On the other hand, ciliary dysfunction may also occur in the fallopian tubes of affected women, leading to an increased risk of ectopic

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Book 2020of genetic abnormalities on male infertility is the subject of part 2,covering sperm defects, mitochondrial function and DNA fragmentation. The clinical case material in part 3 illustrates real-world examples of genetic etiologies and the current diagnostic and therapeutic strategies for conditions

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Molecular Regulation of Sperm Production Cascadeplex process involving the interplay of thousands of genes, of which about 1000 are testis enriched with about 200 signature genes. Such a complex spatiotemporal molecular interplay is mandatory for orchestrating the most diverse cellular changes beginning with mitosis, going through meiosis, and te

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Spermatozoal Chromatin Structure: Role in Sperm Functions and Fertilizationequired for normal embryo development. During spermiogenesis, the formation of mature spermatozoa results in an extreme compacted DNA in sperm nucleus with respect to somatic nucleus. To reach such compaction, a dramatic reorganization occurs in developing spermatids where the vast majority of somat

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Genetic Evaluation of Male Infertilitybnormalities to the very recent discovery of point mutations disrupting spermatogenesis, it is clear that a substantial number of patients suffer from genetic abnormalities. However, the discovery of these causes has largely been limited by the resolutions of the technologies used for patient assess