Titlebook: Gene Therapy Protocols; Jeffrey R. Morgan Book 20022nd edition Humana Press 2002

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https://doi.org/10.1007/978-1-349-13275-1lso are disadvantages, including generally low efficiency and transience of transgene expression. To create more efficient systems, the use of approaches present in natural pathogens has been shown to be helpful. Based on an understanding of these natural components, ligand-polycation DNA delivery s

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https://doi.org/10.1007/978-981-99-1300-8However, applications of this method have been limited by the relatively low expression levels of the transferred gene. Recently, we investigated the applicability of in vivo electroporation for gene transfer into muscle, using plasmid DNA expressing a cytokine as the vector. The results demonstrate

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Measurement of Roads and Pavings,each method having limitations as well as advantages. To develop in vivo gene transfer vectors with high efficiency and low toxicity, several groups have attempted to overcome the limitations of one vector by combining them with the strengths of another.

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https://doi.org/10.1007/978-1-349-03526-7size DNA molecules (therapeutic genes including their endogenous regulatory regions), be used under reduced confinement conditions, be administered repeatedly, and be modified with appropriate ligands that allow specific cell targeting. Until now, many different types of organic compounds have been

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