Titlebook: Gene Therapy Protocols; Paul D. Robbins Book 19971st edition Springer Science+Business Media New York 1997

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Gene Therapy Protocols978-1-59259-591-4Series ISSN 1543-1894 Series E-ISSN 1940-6037

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https://doi.org/10.1007/978-3-663-14660-5 are advantageous for intravascular injection of virus into either portal or systemic circulation. The portal vein provides a direct iv route into the liver. It also theoretically provides an indirect route by oral administration since the portal system drains the gut.

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https://doi.org/10.1007/978-3-322-99450-9o obtain high-titer vector stocks and the narrow host cell range of these vectors. To overcome these disadvantages, we developed a new class of pantropic retroviral vector that has a broadened host cell range and can be concentrated to very high titers (>10. colony forming units [CFU]/mL) (.)

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Getting Lean — Die Verschlankung des Staatesate for the transduction of primary lymphocytes, because gene transfer is mediated by nonimmunogenic vectors and stable vector integration in the target genome is achieved. Stable integration in cells undergoing clonal expansion ensures that the foreign genetic material will be faithfully transmitted to the cells’ progeny.

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https://doi.org/10.1007/978-3-658-03786-4 marker for hematopoietic progenitors (.-.).Enriched HSC populations are being widely investigated for use in transplantation and gene therapy because they appear to provide rapid hematopoietic reconstitution in myeloablated patients (.-.), and they offer good targets for gene transfer (.-.).