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Titlebook: Gene Therapy Protocols; Paul D. Robbins Book 19971st edition Springer Science+Business Media New York 1997

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发表于 2025-3-21 19:02:01 | 显示全部楼层 |阅读模式
书目名称Gene Therapy Protocols
编辑Paul D. Robbins
视频video
丛书名称Methods in Molecular Medicine
图书封面Titlebook: Gene Therapy Protocols;  Paul D. Robbins Book 19971st edition Springer Science+Business Media New York 1997
描述In the last few years, significant advances have been made in the area of gene therapy for both genetic and acquired diseases. Improvement in gene transfer methods has allowed for development of gene therapy protocols for the treatment of diverse types of diseases, including metabolic, cardiovas- lar, and autoimmune diseases, as well as cancer. For example, clinical trials for gene therapy of cancer, cystic fibrosis, ADA deficiency, and arthritis, among others, have been initiated in recent years. It is likely that, in the near future, gene therapy will become a common form of treatment for many different types of diseases. Gene therapy takes advantage of recent advances in many areas of molecular and cell biology, including the identification of new the- peutic genes, improvement in both viral and nonviral gene delivery systems, better understanding of gene regulation, and improvement in cell isolation and transplantation. Because of the different and complex techniques involved in achieving successful gene-mediated therapies, it is difficult for scientists to perform all methods required for gene delivery and subsequent in vivo gene expression. This Gene Therapy Protocols volume
出版日期Book 19971st edition
版次1
doihttps://doi.org/10.1385/0896034844
isbn_ebook978-1-59259-591-4Series ISSN 1543-1894 Series E-ISSN 1940-6037
issn_series 1543-1894
copyrightSpringer Science+Business Media New York 1997
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Methods for Gene Transfer Using DNA-Adenovirus Conjugates,ors have been derived. These vector agents consist of two linked functional domains: a DNA-binding domain to transport the DNA as part of the vector complex, and a ligand domain to target a cellular receptor that allows entry of the conjugate-DNA complex into a receptor-mediated endocytosis pathway.
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Development of Replication-Defective Herpes Simplex Virus Vectors,NS disease will require new delivery strategies and vehicles including the development of novel vectors for direct gene transfer. These vectors should: efficiently deliver the therapeutic gene(s) to a sufficient number of nondividing neurons; persist long-term in a nonintegrated state within the ner
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Methods for Adenovirus-Mediated Gene Transfer to Airway Epithelium,hase I clinical trails are now underway evaluating the safety of recombinant adenoviral vectors for gene therapy of cystic fibrosis lung disease (.). This clinical application of these vectors in CF lung disease presents the largest comprehensive effort of in vivo gene therapy to date. Such a substa
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Methods for Efficient Retrovirus-Mediated Gene Transfer to Mouse Hematopoietic Stem Cells,ethods for stem cell transduction that are effective with mouse cells have only been partially successful in dog, nonhuman primate, and human models. Whereas scale-up of stem cell transduction procedures for human applications will present unique technical problems, mouse models may yet provide furt
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1543-1894 es, it is difficult for scientists to perform all methods required for gene delivery and subsequent in vivo gene expression. This Gene Therapy Protocols volume 978-1-59259-591-4Series ISSN 1543-1894 Series E-ISSN 1940-6037
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Analyses of Processing Contamination,ors have been derived. These vector agents consist of two linked functional domains: a DNA-binding domain to transport the DNA as part of the vector complex, and a ligand domain to target a cellular receptor that allows entry of the conjugate-DNA complex into a receptor-mediated endocytosis pathway.
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