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Titlebook: Gene Targeting Protocols; Eric B. Kmiec Book 2000 Springer Science+Business Media New York 2000

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楼主: Buren
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,Foundation III—Thought Experiments,human clinical trials has been to produce long-term expression of therapeutic genes by integration of the DNA sequences encoding these genes into the chromosomes. Integration strategies include random, site-specific, and precise integration. To date, only random integration of retroviral vectors has
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https://doi.org/10.1007/978-3-030-89140-4ired diseases, with over 100 protocols approved by the National Institutes of Health since 1989. Skeletal muscle is an especially attractive target for gene therapy, because of its accessibility and capability to uptake, maintain, and express recombinant protein from plasmid DNA (.–.). Transduction
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A. Dalhoff,S. Matutat,U. Ullmannon initiation. Research in the past two decades has provided a wealth of information about the mechanisms of transcriptional control in human cells. The analysis of the promoter and enhancer DNA elements, and of the corresponding DNA-binding proteins, has provided an understanding of the basic mecha
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