Titlebook: Gene Targeting Protocols; Eric B. Kmiec Book 2000 Springer Science+Business Media New York 2000

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书目名称Gene Targeting Protocols影响因子(影响力)




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书目名称Gene Targeting Protocols被引频次学科排名




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书目名称Gene Targeting Protocols读者反馈学科排名

chandel

,Old Age and Alzheimer’s Disease in Film,oses, including adeno-associated virus, herpesvirus, and others (.,.). Each virus has advantages and disadvantages: The latter include inactivation by human complement, limited infectivity, low titers, short-lived expression, immunogenicity, contamination by replication-competent or helper virus, and so on.

报复

Konzeptioneller Rahmen und Forschungsstand,ction of the treated cells will acquire the designed change. The overall inefficiency may result from the rarity of precise homologous recombination and from the low frequency of appropriate gene transfer.

紧张过度

G. A. S. Premakumara,W. P. K. M. Abeysekeraally into the host chromosome (ch). Targeting of AAV to ch19.13.3 qter locus has been documented at a frequency of 70% or greater (.). Because of AAV’s unique ability to integrate site-specifically, extensive research has been devoted to understanding how AAV integrates, with the hope of creating targeting vectors for gene therapy.

Spinous-Process

A. Dalhoff,S. Matutat,U. Ullmannhe analysis of the promoter and enhancer DNA elements, and of the corresponding DNA-binding proteins, has provided an understanding of the basic mechanisms of transcription initiation (.). This information is now used to devise gene expression cassettes for gene therapy.

懦夫

懦夫

https://doi.org/10.1007/978-3-030-72147-3)is a technique that has shown promise in this application (.). SFHR has been used to correct the most common mutation associated with cystic fibrosis (CF), a 3-bp deletion in the CF transmembrane conductance regulator .gene, resulting in the loss of a phenylalanine at amino acid position 508 (Δ508) (.–.).

MERIT

BOGUS

Book 2000ation, the cloned gene is returned to its homologous location in the genome and becomes inserted at the target locus. This process is a controlled means for the repair of DNA damage and ensures accurate chromosome disjunction during meiosis. The paradigm for thinking about the mechanism of this p- c

欢呼

Effective Gene Transfer Using Viral Vectors Based on SV40,oses, including adeno-associated virus, herpesvirus, and others (.,.). Each virus has advantages and disadvantages: The latter include inactivation by human complement, limited infectivity, low titers, short-lived expression, immunogenicity, contamination by replication-competent or helper virus, and so on.