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Titlebook: Gene Delivery to Mammalian Cells; Volume 2: Viral Gene William C. Heiser Book 2004 Humana Press 2004

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Delivery of DNA to Lung Airway Epitheliumion of epithelial cells (.–.). Much current work in lung gene therapy is directed toward overcoming the inflammatory and immune responses provoked by gene-transfer vectors while simultaneously maximizing vector delivery and subsequent gene expression.
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Delivery of DNA to Tumor Cells In Vivo Using Adeno-Associated Virusects either to replace a defective protein/enzyme or to elevate their otherwise suboptimal levels in the system. However, increased understanding of both the biology of tumor progression and potential utility of AAV-based vectors suggests that this vector can also be wisely used for cancer gene therapy.
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Adenovirus-Mediated Gene Deliveryange of mammalian species. Human adenoviruses are classified into six subgroups based on the percentage of guanine and cytosine in the DNA molecules and the ability to agglutinate red blood cells. They are further subdivided into more than 50 serotypes, primarily on the basis of neutralization assays (reviewed in ..).
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Adenovirus-Mediated Gene Deliveryiruses constitute the . family, which is divided into two genera: the . genus infects only birds, whereas the . genus contains viruses that infect a range of mammalian species. Human adenoviruses are classified into six subgroups based on the percentage of guanine and cytosine in the DNA molecules a
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Adenovirus-Mediated Gene Delivery to Skeletal Muscledenoviral vectors awaits the development of methods to allow safe and efficient targeted gene delivery to mature skeletal muscle upon intravenous vector administration (.), the current generation of vectors has nonetheless found utility in preclinical studies of gene therapy and in gene-transfer exp
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Gene Transfer to Brain and Spinal Cord Using Recombinant Adenoviral Vectorscause respiratory and gastrointestinal infections. Forty-three different human adenovirus serotypes have been characterized (.). Details about production of recombinant Ad vectors are given in .. Ad vectors in widespread use are derived from human Ad serotypes 2 and 5 (Ad2 and Ad5), Ad5 being more c
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