Titlebook: Efflux-Mediated Antimicrobial Resistance in Bacteria; Mechanisms, Regulati Xian-Zhi Li,Christopher A. Elkins,Helen I. Zgurska Book 2016 Spr

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Antimicrobial Drug Efflux Pumps in ,isolates have been found in both humans and animals and thus pose a major public health concern. Drug resistance in . has been shown to be largely attributable to multiple target gene mutations and to active efflux by pumps. At least ten drug efflux system genes in the genome of this organism have b

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Antimicrobial Drug Efflux Pumps in , and ,p. These Gram-negative bacteria exhibit a rapid and efficient adaptation to antimicrobial agents and are responsible for several healthcare-associated infections. The modification of the transporters involved in the drug translocation through membrane barrier represents the first line of bacterial d

傲慢人

Antimicrobial Resistance and Drug Efflux Pumps in , and ,esentative species, ., ., and ., are generally susceptible to a range of antimicrobial agents, but their resistance to antimicrobials can be readily selected after exposure to antimicrobial agents. The genomes of these species contain a large number of genes encoding proven and putative drug efflux

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Antimicrobial Drug Efflux Pumps in ,y to different antimicrobial agents that are currently in use in the clinical practice. Because of that, this species is considered as a prototype of intrinsically resistant microorganism. Part of its capability to resist the action of antimicrobials resides in a number of chromosomally encoded effl

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Antimicrobial Drug Efflux Pumps in ,enus are opportunistic pathogens, especially for immunocompromised and cystic fibrosis patients. Of note, they show a high level of intrinsic drug resistance, and many genes encoding virulence factors were identified in their genomes. Main contributors to antimicrobial resistance of these bacteria a

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Descriptions, Translations and the Caribbeanhapter provides an overview of molecular and biochemical mechanisms of antimicrobial resistance with an emphasis on the role of drug efflux pumps and their relationship with other key resistance mechanisms in clinically relevant intrinsic and acquired resistance.