Titlebook: Efflux-Mediated Antimicrobial Resistance in Bacteria; Mechanisms, Regulati Xian-Zhi Li,Christopher A. Elkins,Helen I. Zgurska Book 2016 Spr

Cirrhosis

978-3-319-81934-1Springer International Publishing Switzerland 2016

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Structures and Transport Mechanisms of the ABC Efflux Pumpsre they are involved in the influx or efflux of various molecules. Although bacterial drug efflux transporters were initially discovered as ion-motive-driven pumps, evidence has accumulated since the mid-1990s that members of the ABC superfamily can play a prominent role in drug resistance mechanism

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Multidrug Efflux in the Context of Two-Membrane Cell Envelopesters include periplasmic membrane fusion proteins and outer membrane channels due to the presence of a double membrane. These complexes are highly versatile and constitute a major antimicrobial resistance mechanism of Gram-negative bacteria. The modular organization of the tripartite assemblies in G

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botany

Antimicrobial Drug Efflux Pumps in ,ux pumps (represented by AcrAB-TolC system) were identified in this species. Several of these efflux systems have served as prototypical pumps for characterizing substrate specificity, transport mechanisms, regulation, and inhibition of bacterial drug transporters. Efflux pumps are encoded by chromo